Vaccine antibodies kill many Klebsiella strains in lab tests
Researchers tested whether vaccine-induced antibodies against a surface sugar of Klebsiella pneumoniae can kill clinically important strains of the bacterium. They report that the antibodies killed many strains. The work is peer-reviewed and appears in Nature Communications.
The surface sugar is called lipopolysaccharide. The researchers say the result supports simpler vaccine designs against neonatal sepsis and antibiotic-resistant infections. Klebsiella pneumoniae is a drug-resistant bacterium that causes serious infections in newborns. The findings come from laboratory work, and the approach has not yet been tested as a vaccine in people.