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England trial tests blood checks for earlier cancer diagnosis

A clinical trial in England will test whether family doctors can use simple blood tests to spot some common cancers sooner. At least 200 GP practices will take part, covering more than 20,000 patients.

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The University of Birmingham developed the tests. They look for signs of several cancers in a blood sample and suggest where in the body the cancer comes from.

Patients aged 45 and over who visit a GP with abdominal symptoms can take part. The practices belong to the National Health Service (NHS) in England.

The trial will measure how well the tests support the judgment of GPs. The results will help decide whether to roll the tests out nationally. Reports described it as a world first, and noted that cancer mortality in Britain is among the highest of OECD countries per person.

Science

Kruger Park faces R481 million gap to fix flood damage

Environment Minister David Maynier said the park still lacks R481 million to repair roads, bridges and accommodation damaged in January floods. Repairs are estimated to cost R950 million, and R87 million has been spent so far.

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Projects worth R188 million have been approved so far. South African National Parks (SANParks) set aside R100 million for the repairs. National government allocated R218 million, and an insurance settlement added R150 million.

About 90,000 guests visited the park in February 2026. That was 7,000 fewer than in February 2025. The park had 1.87 million visitors in the 12 months through March 2025.

Science
A yellow submersible research vehicle hovers above the seafloor in clear blue water.

Earthquakes feed carbon storage in the deepest ocean trenches

A peer-reviewed paper in Nature Communications reports that earthquakes push organic matter into hadal trenches, the deepest parts of the ocean. The authors say this supports ongoing formation of authigenic carbonates.

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The authors argue that these carbonates are an overlooked carbon sink. They also suggest the carbonates could be a route for carbon to move into the deep Earth. The work links seabed earthquakes to the way carbon is locked away on the ocean floor. The carbon sink claim is the authors' own view, and it has not been independently checked.

Science
A blue reservoir lake lined by dry, rust-coloured hills under a clear sky.

Study says green hydrogen for Europe may strain north Africa's water

A materials and environmental science researcher and co-author Mustafa Gazi modelled a 1-gigawatt green hydrogen plant in a hot, dry climate. They found it needs far more water than the industry claims.

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The model counts water for making hydrogen, treating supplies and cooling equipment. It puts use at 35 to 170 litres per kilogram of hydrogen, against the industry claim of about nine litres. The authors say desalination would release salty, chemical-laden wastewater that could harm marine life, and that old groundwater could run out. They write about Morocco, Algeria and Egypt, which want to supply Europe. This is a modelling study, so its results depend on its assumptions.

Science

Loss of one neuron type may dull spatial memory in old mice

A study in Nature Communications reports that ageing impairs spatial-coding cells in the medial entorhinal cortex of mice. It identifies a neuron type marked by the gene Bglap3.

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The researchers suggest that losing these Bglap3 neurons with age may contribute to the decline in spatial memory. The work is peer-reviewed. It gives scientists a specific cell type to study further. The findings come from mice, and the link to memory decline is a suggestion, not proof. The work is far from applying to people.

Science
A small streaked songbird perched on a bare branch against a pale blurred background.

Study finds human speech and birdsong share sound patterns

Researchers compared the songs of 367 bird species with speech and song from 52 human languages. Their peer-reviewed study in Science reports shared patterns, such as longer final syllables at the end of phrases.

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The team, including Logan, Jon and Kendra, annotated more than 70,000 birdsong syllables from public recordings. Both birds and humans kept pitch changes small between neighbouring syllables and used regular rhythms. Birds that learn their songs did not differ clearly from those that do not. The authors say they need more studies to explain the patterns. Their idea is that breathing and vocal muscles may shape them.

Science

MIT pair win prize for AI-led antibiotic discovery

Regina Barzilay and James Collins, professors at the Massachusetts Institute of Technology (MIT), won the 2026 Pritzker Prize for AI in Science Research Excellence. The University of Chicago and Caltech give the prize for their work on finding antibiotics with AI.

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The pair used deep learning to find halicin in 2020, from a model trained on 2,500 molecules. It killed drug-resistant bacteria in tests. In 2023 they found abaucin, which targets one species, A. baumannii. Barzilay says drug discovery is still at an early stage and AI can automate only parts of the process. MIT, the winners' own institution, announced the award.

Science

Study records a bull and a male donkey mating in Ethiopia

Researchers watching gelada monkeys in Ethiopia noticed a bull named Achille and a male donkey named Patroclo having sex repeatedly. Their study appears in the peer-reviewed journal Current Biology.

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The team recorded 51 mounting attempts, 34 of which involved penetration. The donkey often initiated contact, and the pair showed affection afterwards. The authors suggest that sex may help maintain their bond. A primatologist, writing about the study, notes that same-sex behaviour has been reported in more than 1,500 animal species. The researchers watched the pair closely for only four days, so they cannot say how long the relationship lasted.

Science
A large grey flint core with worked flake scars rests on stones outdoors.

Old flint tools show Egyptian villagers specialised before the pharaohs

A team of archaeologists who study north African prehistory re-examined almost 3,000 flint tools from Heliopolis, dug up near Cairo in 1905 and 1906. They say specialised tool-making was already shaping village life before Egypt became a state.

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The flints sat in 40 boxes in Turin for over a century. Using faded labels and the notes of the Egyptologist Ernesto Schiaparelli, the team linked the objects to Heliopolis. Many cores but few blades suggest one area was a workshop that made more blades than its own knappers needed. The authors present this in their own article on a new study, so it is not a peer-reviewed text, and it rests on century-old excavation records.

Science

Fishers and green groups demand sardine fishing pause

Environmental groups and small-scale fishers want the Department of Forestry, Fisheries and the Environment to be more open about a mass sardine die-off along roughly 2,600 kilometres of coastline. They want fishing suspended until a new survey is done.

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The die-offs are linked to the pilchard herpesvirus. The government has temporarily restricted commercial fishing catches. The groups want a full suspension until a new biomass survey ends and an updated catch limit is announced.

Neville Van Rooy, spokesperson for The Green Connection, said nobody yet knows how bad the damage is. He said the scale must be checked and made public. He warned that continued fishing could harm the fish population more.

WWF South Africa wants a total ban on sardine fishing. The department said there was not enough evidence to justify a complete ban. Fishers and conservationists say the government lets fishing go on despite doubt about the outbreak's effect on stocks.

Fishing communities said falling sardine numbers could threaten livelihoods and food security.

Science

Tshwane mayor tells Bronkhorstspruit residents not to drink tap water

Mayor Nasiphi Moya said the water has not been declared safe while testing continues. Tests found a low level of E. coli in discharge during cleaning of a sump at the Bronkhorstspruit Water Treatment Plant.

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Moya briefed the media on progress to fix the Bronkhorstspruit Water Treatment Plant. The City of Tshwane failed to chlorinate water from the plant. Over 800 cases of gastrointestinal illness were reported in the area last month.

The E. coli was found in water discharged while workers cleaned the clear water sump. The city will repeat disinfection until the contamination is gone.

Moya said videos are circulating, including some by councillors, that show water coming out of reservoirs. She said residents must not use the water even where it looks clean.

Science

Dutch team builds a soft robot arm powered by algae

Researchers at Delft University of Technology in the Netherlands built a small strip of two hydrogel layers with microalgae growing on it. It bends back and forth as the light changes, and it can grasp and lift small objects. The work is peer-reviewed in Nature Communications.

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Professor Marie-Eve Aubin-Tam led the work, and PhD candidate Fan Jiang was first author. In light, the algae make sugars through photosynthesis and raise the pH in the hydrogel. The two layers swell by different amounts, so the strip bends. In the dark the pH falls, and the strip starts to bend the other way within 10 seconds. The strip is about 2 cm long and 1 mm thick. Aubin-Tam calls it a proof-of-concept, and the team had no specific application in mind.

Science

Water department urges Gauteng residents to cut water use

The Department of Water and Sanitation says a heatwave in its third consecutive week and a likely strong El Niño put summer supplies at risk. It warns that heavy use by residents with water could leave areas with disruptions short.

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Department spokesperson Wisane Mavasa said the heatwave is pushing up demand across Gauteng. She said leaking municipal pipes and high use per person add to the problem. The department said Gauteng uses about 250 litres per person a day, against an international average of 173 litres.

The department put non-revenue water at an estimated 47% and physical water losses at about 27%. It said the South African Weather Service forecasts a high likelihood of a strong El Niño in the 2026/27 summer. The department said El Niño could cut dam inflows, raise evaporation and increase demand.

The department said it cannot give Rand Water more than the volume already allocated to it from the Integrated Vaal River System. Mavasa said the department will cut the water that farms, industries and other users, including water boards, may draw where this is needed. She urged residents to follow municipal water restrictions and make saving water a daily habit.

Science
Rows of plain glass test tubes in a wooden rack on a laboratory bench.

AI tools for gene variants may score better than they should

A study in Nature Communications finds that AI models that predict disease-causing single-nucleotide variants look more accurate than they are. The problem arises when tests mix different types of variant.

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The authors say benchmarks that combine variant types, such as canonical splice and 5' UTR variants, inflate the scores of these models. They propose a stratified benchmark that separates the types, and they use it to identify the most robust models. The study is peer-reviewed. Only a short summary was available, so the methods and results are not described here.

Science
Pale fossil bone fragments lying on dark soil, with blurred grass in the background.

Study maps gene changes behind the evolution of the human skeleton

Gokhman, Inoue and colleagues built a genome-wide atlas of human-specific changes in gene regulation, using cartilage cells called chondrocytes. The work appears in the journal Nature.

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The atlas also lists the DNA sequence variants that drive these changes. The researchers aim to explain how the human skeleton evolved, including the adaptations for walking upright. The work is peer-reviewed. The details given here come from a summary of the study, not the full paper, so the findings and methods need checking against the paper itself.

Science
Golden sand dunes rolling across a desert beside a rocky outcrop under a pale sky.

Early humans settled where water and tool stone met

A research team surveyed about 1,500 km of the Rub' al Khali, the world's largest sand sea, and modelled the Arabian Peninsula. They suggest early human settlement followed places with both water and stone suitable for tools.

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The study is peer-reviewed and appears in the journal Nature. The team found almost no stone tools around ancient lakes, which led to the idea that water alone did not decide where people lived. This may matter for how researchers read dispersal routes, including those out of Africa. The survey was a single 35-day transect in 2023, so the conclusion rests on missing evidence plus modelling.

Science

New extinct crocodile found in the rock of the Sphinx

Palaeontologist Karim Zanaty and colleagues describe Herugavialis cairensis, a new extinct gavial crocodile. The fossil came from the Mokattam Formation in Egypt, the rock used to carve the Great Sphinx of Giza.

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The team, led by Paul Burke of the Swedish Museum of Natural History, used CT scans to re-examine a skull first described in 1927. They found differences from Tomistoma, including raised rims around the eye sockets. Zanaty says the work may help explain how gavials once lived across the globe, while only two endangered species survive. This account is a first-person piece by the researchers, not the peer-reviewed paper.

Science
Concrete reservoir wall holding back water under a grey sky.

Johannesburg needs R13bn to fix ageing water network

Mayor Dada Morero said the city needs about R13bn: R6bn for water and R7bn for sewers. He said the network of more than 70 years loses 44% of its water to leaks, bursts and failing pipes.

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Morero spoke at a media briefing at the Crown Gardens reservoirs on Monday. He said the loss of water has crippled supply while reservoirs run low. Outages continue in parts of the city.

The city's pipe network is 12,600km long. Johannesburg Water replaced 84km of pipe in the last financial year. Morero said the scale of the problem is enormous.

He said steps in the Johannesburg Water turnaround strategy could cut losses by at least 10% in the short term. He said this would come at a massive cost.

Morero also said the city's high consumption exceeded the allocation from Rand Water, and the city is battling to meet demand. He said Johannesburg Water officials are working around the clock to restore supply.

Science
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New electrochemical sensor detects single cancer cells in blood

Researchers report a sensor that detects single circulating tumour cells in blood. The work appears in the peer-reviewed journal Nature Communications.

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The team found an electron-transfer effect in which only redox probes at the cell-electrode interface produce measurable current. They used it to build an electrochemical sensor. On 55 patient samples, the sensor showed 96% specificity and 87% sensitivity. The sample is small, and the figures are early and not independently validated. The work does not say whether the test will be available in South Africa.

Science
A gloved researcher in a mask holds up a stained tissue slide in a laboratory.

Overactive interferon signalling may explain lung problems in Down syndrome

A study in Nature Communications reports that overactive type I interferon signalling in lungs with trisomy 21 (Down syndrome) makes lung epithelial cells mature too early. The authors link this early maturation to lung abnormalities seen in people with trisomy 21.

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The peer-reviewed work offers a possible biological explanation for lung problems that affect many children with Down syndrome. The summary we read gives no sample sizes or methods. The findings may come from lab or animal models, so they need further testing before anyone can say how they apply to patients.

Science
Clear glass test tubes and petri dishes on a laboratory bench in soft daylight.

Study links excess phosphate to heart enlargement in kidney disease mice

A study in Nature Communications reports that excess phosphate activates an enzyme called GLS1 in mice with chronic kidney disease. The enzyme drives enlargement of heart muscle cells.

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The researchers found that blocking GLS1 protected male mice against this heart enlargement. Heart enlargement is a common and serious complication of chronic kidney disease, so the enzyme may be a possible drug target. The work is peer-reviewed but early and preclinical. It used male mice only, and it has not been tested in people.

Science
Glass beakers, flasks and measuring cylinders holding clear liquid on a white surface.

Small molecule aids DNA repair and extends life in mice

A study in the journal Nature Communications reports a small molecule that activates a protein called KIF2C. The compound improves repair of DNA double-strand breaks in aged cells.

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The authors say the compound also extends lifespan in mice with progeria, a model of premature ageing. The study is peer-reviewed, but only the abstract was available for this post. The work used cells and mice, so its relevance to people is unknown. The findings are early and far from any use in humans.

Science

Silk microneedles could vaccinate farmed fish with less stress

Researchers at MIT and the US Department of Agriculture have made water-resistant microneedles from food-grade silk. The peer-reviewed paper in ACS Nano shows the needles can deliver cargos such as bacterial vaccines.

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Professor Benedetto Marelli of MIT's Department of Civil and Environmental Engineering led the work. The needles lightly penetrate fish skin, stay attached and then decompose. Today's most effective method uses metal needles, and workers must sedate and inject fish one by one. The team calls its approach "potentially better", but the evidence comes from lab work, and it has not been tested on farms.

Science

Weak brain current removes bias in recognising sexualised women

Researchers used a mild electrical current on the forehead to change how people recognise sexualised images of women. The peer-reviewed study appears in the journal Social Neuroscience.

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In the study, 76 university students tried to memorise photos of models in underwear, then said which photos they had seen. Half received a weak current for ten minutes and half received a placebo. In the stimulated group, recognition of upright women improved and the gap between images of men and women disappeared. The authors say it was a single lab session with students, and they measured only immediate effects, not attitudes or behaviour.

Science

Deep-sea worm-like mollusc found with new bacteria-housing structure

Researchers have described a previously unknown structure inside Chaetoderma shenloong, a worm-like mollusc that lives in oxygen-free cold seep sediment. They named it "dracosphera", which means "dragon ball".

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The structure has many layers and houses bacteria that make energy from chemicals, not sunlight. The findings suggest the animal may host these bacteria inside a dedicated part of its cells. The work is peer-reviewed and appears in Nature Communications. Only the opening of the abstract was available, so the sample size and methods are not known.

Science
A flexible translucent soft robot tube with ribbed segments on a white laboratory bench.

MIT engineers design soft robot to move through small intestine

Engineers at MIT have designed a soft robotic enteroscope that inches through the small intestine using a snake-inspired motion. The study appears in the peer-reviewed journal Science Robotics.

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Professor Giovanni Traverso, a mechanical engineer at MIT and a gastroenterologist, led the work. A textured coating helps the robot grip the intestinal lining, and it can carry tools for imaging, biopsies, removing small polyps and delivering drugs. The team wants an easier and faster option than double balloon enteroscopy, which they call slow and laborious. The text shown does not report results in patients, so the clinical benefit is not yet shown.

Science
Bundle of white insulated wires on a laboratory bench with a soft blue glow.

MIT study links APOE4 gene to faulty brain insulation

Researchers at MIT report that the APOE4 gene variant, the biggest genetic risk factor for late-onset Alzheimer's, suppresses Wnt signalling in oligodendrocytes. These are the brain cells that make myelin, the insulation around neurons.

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Professor Li-Huei Tsai and Leyla Akay, a former graduate student, led the study in the peer-reviewed journal Cell Stem Cell. When the team restored Wnt signalling, myelination recovered in human cell cultures and in mice modelling Alzheimer's. They did this by inhibiting a protein called GSK3b. The work used cell cultures and mice only, so it has not been tested in people.

Science

Team maps family tree of over 1 million mouse embryo cells

Researchers in the lab of Professor Jonathan Weissman at MIT's Whitehead Institute tracked the family history of over a million cells in developing mouse embryos. The study, with Yale University and the Max Planck Institute for Molecular Genetics, appears in the peer-reviewed journal Cell.

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The team used a tool called PEtracer, which makes small DNA changes that pass to daughter cells, so scientists can work backward to find each cell's ancestors. They combined these trees with data on gene activity and cell position. The researchers say the map could help explain birth defects and cancer, and guide stem cell research. The work was done in mice, so any link to human health is still indirect.

Science

First human trial tests new antibody-drug for solid tumours

A first-in-human trial tested AZD8205 (puxitatug samrotecan), an antibody-drug conjugate that targets the B7-H4 protein, in patients with advanced solid tumours. The peer-reviewed results appear in Nature Communications.

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The Phase 1/2a study, called BLUESTAR, reports the drug's safety and how well it worked in heavily pretreated patients. These patients had ovarian, endometrial or breast cancer, or cholangiocarcinoma. It is an early look at a drug that could matter for gynaecological and breast cancers. It is an early-phase trial with small samples, and the drug is not yet proven in larger studies. AstraZeneca, the drug's developer, ran the trial.

Science

Study maps where SARS-CoV-2 proteins bind viral RNA

A peer-reviewed study in Nature Communications mapped where three SARS-CoV-2 proteins, NSP8, NSP12 and N, bind the virus's RNA during infection. The authors used a method called genome-scale eCLIP.

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The authors report regulatory sites on the viral RNA that appear to control how the virus copies itself and makes proteins. They suggest these sites could become targets for antiviral drugs. This is early work: the antiviral potential is speculative, and no drug has been tested against these sites.

Elections Hot

What you need to know

Voting in the 2026 Local Government Elections is under way at 23,696 stations, and the Electoral Commission of South Africa (IEC) reported a smooth start on 4 November. Stations opened at 7am and close at 9pm, and by 10am preliminary figures showed 3,523,691 voters had cast ballots.

There were problems: unused ballot papers were stolen from Mnyameni Secondary School near Durban, police opened a case, and the IEC relieved the station staff of duty. Some voters in Tshwane said they were turned away for wearing party shirts, but the IEC denied this and said only mayoral candidates' entourages were barred.

ANC chairperson Gwede Mantashe told members not to query the results or discredit the IEC, while the IEC said false online claims show routine procedures as fraud.

  1. IEC dismisses MK Party worry about dead people on voters' roll
  2. IEC says local election voting went largely smoothly
  3. IEC says about 12 million had voted by 5pm

See every update

AI Hot

What you need to know

Nvidia has told its cloud computing clients to sell at least 51% of their services to non-Chinese companies, according to five people with knowledge of the matter. Anthropic said it has committed to spend close to $900bn on AI infrastructure, and that its computing costs are rising faster than its revenues.

Elsewhere, reports from unnamed sources say OpenAI's latest funding round is falling short of expectations, and a judge let the NAACP pollution case against xAI proceed. In South Africa, the VAST AI investment scheme went offline on 30 October after withdrawals marked approved did not arrive, according to a news investigation.

  1. Accenture faces accusations over AI report with false citations
  2. CrowdStrike to buy two AI security startups
  3. Google lets schools turn off AI tools but limits Search

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US mid-terms Heating up

What you need to know

Democrats won back both the US House and Senate in the midterm elections held on 3 November, according to media projections. Exit polls showed voters were angry about high prices and the direction of the country, and rebuked President Donald Trump.

Before the vote, US forces struck targets on Qeshm Island in Iran, while Republicans struggled to defend the war against Iran on the campaign trail. Iranian officials said US voters rejected the war, and Tehran stayed on high alert for possible new US strikes.

Markets reacted, with the dollar hitting a one-month low and the rand firming to around R16.55, as analysts pointed to fears of gridlock in Washington.

  1. Iran welcomes Democratic wins in US midterm elections
  2. Democrats win US Congress in midterm vote, projections show
  3. Ramaphosa wants US trade deal after AGOA suspension

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